Goalkeeper Emiliano Martinez, 22, is set to make his Champions League debut for Arsenal at Anderlecht on Wednesday.
First-choice Wojciech Szczesny is suspended, while Colombia international David Ospina has a thigh problem.
Defender Calum Chambers is available after a domestic ban, while forward Lukas Podolski has overcome an illness.
Centre-back Laurent Koscielny (Achilles) and forwards Mesut Ozil (knee), Yaya Sanogo (hamstring) and Olivier Giroud (foot) are all out.
Theo Walcott is not yet fully fit as he recovers from a nine-month injury lay-off, while France full-back Mathieu Debuchy also remains a long-term absentee with an ankle problem.
Argentine Martinez has made two appearances for the Gunners since joining the club in 2011, with both of those starts coming in the League Cup.
Englishman Ryan Huddart, 17, will be on the bench as his back-up.
Arsenal are second in Group D with three points from two matches, three points behind leaders Borussia Dortmund. Anderlecht are third, level on one point with bottom side Galatasaray.
Arsenal manager Arsene Wenger, who celebrates his 65th birthday on Wednesday, said: "It is a big game for us and I just dedicate all my energy to getting things right to perform, because at the moment I feel there is a difference between the quality of our performances and the points we get.
"We want to add something to the quality of our performance and get the points that you feel is there in the team. That little percentage we can improve in the team is vital and I hope we get it."
Despite the Gunners travelling with a depleted squad, Anderlecht manager Besnik Hasi insists his side, who are top of the Belgian league and unbeaten after 11 matches, will not underestimate their opponents.
"Arsenal are playing in the Premier League every week - they are playing big games," he said. "We are playing in a smaller competition and we need these types of games to get better.
"We are a very young, talented team. But for us it will be a mistake if we are thinking that because Arsenal are missing some players and have not been at their top level in their competition, they will not be difficult opponents. That mistake will not happen here
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